Abstract: Southwest China has a typical fragile agricultural weather, where agricultural weather disaster occurs excessively. Meanwhile, the ability to prevent agricultural weather disaster is too weak to reduce the harm. So, it plays a great role in increasing production and farmers’ income, and ensuring grain security, environment security and agricultural sustainable development. Based on the comprehensively analysis of the kinds and its harm of agricultural weather disaster, this paper indicated that the key problem of agricultural weather disaster prevention and control is：(1)enhance the collaboration between agriculture department and weather department to increase the of precision and practicability of forecast;(2)intensify the integration and innovation of technology to break through the comprehensive prevention and control technology under multi agricultural weather disaster occurred at the same time; (3) reform the mechanism of demonstration to decrease the cost of agricultural weather disaster prevention and control. 