Based on MODIS NDVI data from 2000 to 2016, the distribution pattern and dynamic change characteristics of vegetation coverage in the Manas River Basin of Xinjiang were studied by using the dimidiate pixel model and the spatial analysis of ArcGIS, and the spatial distribution differences of vegetation cover change in elevation, slope and aspect were analyzed. The results showed that: (1) the Manas River Basin was dominated by low vegetation cover, the area of high-level vegetation coverage was significantly increased, and the other levels were less volatile. The area ratio of vegetation cover improvement (31.17%) was much larger than the proportion of degraded area (16.1%) during the study period, the overall vegetation coverage of the study area increased, and the ecological environment improved. (2)In the area of elevation <800m and slope <8°, the vegetation coverage was obviously improved. The vegetation significantly degraded areas were mainly distributed in the elevation of 1300-3400m, the slope was >25°, and the area where the vegetation coverage had not changed was mainly concentrated in the elevation > 3600m. (3)When the elevation was >2100m, the vegetation coverage tended to decrease with the increase of elevation. In the area below 2100m, the vegetation coverage fluctuated greatly with the increase of elevation. (4)With the increase of slope, the vegetation coverage gradually decreased. The vegetation coverage was the largest (42.69%) in the 0?5 degree slope of the whole basin. (5)The difference of vegetation coverage was not significant in all aspects. The vegetation coverage on the flat ground was the largest (44.21%), and the vegetation coverage on the shade aspect was better than the sunny aspect. There was no obvious difference of the vegetation coverage change except in the flat ground.