Based on the daily maximum temperature and minimum temperature data of 38 meteorological stations in Xizang from 1981 to 2023, 11 extreme temperature indices were selected for this study. Methods including trend analysis, the Mann−Kendall mutation test, and wavelet period analysis were employed to systematically investigate the spatiotemporal evolution characteristics of extreme temperature indices in Xizang. The study aimed to clarify the core features, mutation points and periodic response mechanisms of these indices on the plateau under climate warming, providing a scientific reference for climate change adaptation, ecological environmental protection and disaster prevention and mitigation policy formulation in the region. The results showed that: (1) temporally, three cold indices from 1981 to 2023 (frost days FD, cool nights TN10p and cold spell duration index CSDI) across Xizang showed a significant decreasing trend (P<0.01), with FD exhibiting the most pronounced decline. In contrast, warm indices (warm days TX90p, warm nights TN90p and warm spell duration index WSDI) and extreme indices (monthly maximum of daily minimum temperature TXn, monthly minimum of daily maximum temperature TNx, annual minimum of daily minimum temperature TNn and annual maximum of daily maximum temperature TXx) all showed a significant increasing trend (P<0.05), with TN90p showing the most notable increase. Other indices (daily temperature range DTR) exhibited a fluctuating decreasing trend. Mutation analysis revealed that the cold indices underwent significant shifts in the late 1990s and continued to decline thereafter, while the warm indices surpassed the significance threshold after 2000 and continued to intensify. (2) From 1981 to 2023, all 11 extreme temperature indices in Xizang exhibited multi−scale periodic oscillations. The main characteristic was that the cold indices persistently remained in a the low−temperature phase on short−term scales, whereas the warm indices, extreme indices and other indices mostly showed sustained high−temperature features at corresponding short−term scales. (3) Spatially, the cold indices (FD, TN10p and CSDI) from 1981 to 2023 showed a significant decreasing trend in Lhasa, Shannan and the western and eastern parts of Nagqu. The warm indices (TX90p, TN90p and WSDI) exhibited significant increases across almost the entire Xizang. Over 80% of the region displayed an increasing trend for the extreme indices (TXn, TNx, TNn and TXx). At the same time, the DTR index decreased in the western and eastern parts of Xizang, showing distinct spatial heterogeneity. High−altitude regions responded particularly significantly to climate change, with a sharp decrease in the cold indices in the central−western Nagqu region contrasting distinctly with a dramatic increase in the warm indices in the northeastern part of the region, highlighting clear spatial contrasts.